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Typical simulated pharmacokinetic profile of 4 g piperacillin (target Cmax = 240 μg/ml; r2 = 0.97) (a) and 0.5 g tazobactam (target Cmax = 30 μg/ml; r2 = 0.99) (b) administered every 8 h. An elimination half-life of 1 h was simulated for both agents. Open squares represent observed concentrations, and continuous lines represent the best-fit model.
