FIG 1.

Sofosbuvir triphosphate and NsP4 interactions. (A) Structural representation of the nsP4 model of CHIKV and its interaction with SFV and UTP. Hydrogen bonds and electrostatic interactions between SVF (B and C) and UTP (D and E) and nsP4 model of CHIKV. The interactions are represented by blue (H-bonds), green (attractive electrostatic interactions), and red (repulsive electrostatic interactions) interrupted lines. The nitrogen atoms are shown in blue, oxygen in red, fluor in pink, and the carbon chain in gray.