FIG 2.

Inhibition of CHIKV replication in hepatoma cells. Huh-7 cells (10⁴ cells/well in 96-well plate [A] and 2.10⁵ cells/well in 24-well plate [B]) were infected with CHIKV at an MOI of 0.1 and exposed to various concentrations of sofosbuvir, ribavirin, or mycophenolic acid for 24 h. Supernatant was harvested, and virus content was determined by measuring RNA levels (A) or titers (B) in Vero cells. The data represent means ± standard errors of the means (SEM) from five independent experiments.