FIG 5.

Representative CHIKV-associated paw edema and sofosbuvir protection. The hind paws of mock-infected, CHIKV-infected (untreated), and CHIKV-infected/treated animals at the 6th day after infection are displayed. Red arrows indicate the infected paw (A to C). Histopathology data representing H&E-stained sections of paws at 40× (D to F) and 100× (G to I) are presented. Panels A, D, and G represent the mock-infected group. Panels B, E, and H represent the CHIKV-infected and untreated group. Panels C, F, and I represent the CHIKV-infected group treated with sofosbuvir. Images are representative of at least 5 animals per group.