FIG 7.
Sofosbuvir prevented neuromotor impairment of CHIKV-infected mice. Three-day-old Swiss mice were infected with CHIKV (2 × 102 PFU) and treated with sofosbuvir (SF) beginning at 1 day before infection (pretreatment) or 2 days after infection (late treatment). (A) Treatment was performed with a dose of 20 mg/kg/day. (B) Pretreatment was performed with the indicated concentrations. At the sixth day after infection, animals were turned on their backs and allowed up to 60 s to return upright. The results are presented as means ± SEM. This was a routine measure, and at least 10 animals per group were analyzed. Student's t test was used to compare untreated CHIKV-infected mice with other groups individually. *, P < 0.01 mock- versus CHIKV-infected animals. #, P < 0.01 untreated versus treated animals.