FIG 4.

Association between piperaquine concentration and probability of wild-type or mutant genotype among women in the second trimester receiving DHA-PQ. Probabilities of detecting pfmdr1 86 (A) or pfcrt 76 (B) genotypes are shown, with closer visualization of the curves enclosed in boxes shown for pfmdr1 86 (C) and pfcrt 76 (D). Arrows indicate the median concentrations (ng/ml) providing 99% protection against parasitemia. Lines indicate the median probabilities, and the shading indicates the probability of detecting mutant parasites for 95% of the population.