TABLE 3.
Predicted number of mutant infections after starting chemoprevention per 1,000 pregnancies by dosing regimena
| Piperaquine dose | No. of infections per 1,000 pregnancies (95% CI) |
pfmdr1 86Y mutant infections |
pfcrt 76T mutant infections |
||||
|---|---|---|---|---|---|---|---|
| No. (95% CI) | Ratio (DHA-PQ/SP) | P value | No. (95% CI) | Ratio (DHA-PQ/SP) | P value | ||
| 0 mg (SP) | 2066 (1988–2162) | 607 (570–650) | 1564 (1495–1564) | ||||
| 2,880 mg monthly | 317 (280–358) | 198 (165–232) | 0.32 | <0.001 | 283 (248–315) | 0.18 | <0.001 |
| 960 mg weekly | 105 (85–122) | 87 (71.0–104) | 0.14 | <0.001 | 99 (80.4–115) | 0.06 | <0.001 |
| 160 mg daily | 8.0 (4.0–14.0) | 8.0 (3.5–13.5) | 0.01 | <0.001 | 8.0 (4.0–14.0) | 0.005 | <0.001 |
| 320 mg daily | 1.0 (1.0–2.1) | 1.0 (0.96–2.1) | 0.002 | <0.001 | 1 (1.0–2.1) | 0.001 | <0.001 |
a
Estimated based on monthly surveillance for parasitemia in the absence of indoor residual spraying of insecticide or seasonal variation in transmission.