TABLE 1.
Cefazolin concentrations in plasma and cerebrospinal fluid after 8 or 10 g daily administered in continuous infusion
| Parameter | Cefazolin concentration (median [interquartile range]) after: |
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|---|---|---|---|---|---|---|
| 10 g/day |
8 g/day |
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| Plasma (n = 5) | CSF (n = 5) | CSF/plasma ratio (%) | Plasma (n = 5) | CSF (n = 6) | CSF/plasma ratio (%) | |
| Total concentration (mg/liter) | 118 (10) | 12 (1.8) | 12.0 (0.9) | 66.5 (6.6) | 6.1 (1.8) | 10.0 (1.3) |
| Free concentration (mg/liter) | 26.2 (8.9) | 11.9 (1.7) | 54.1 (9.97) | 8.5 (1.4) | 6.1 (1.4) | 73.1 (26.3) |
| Free fraction (%) | 22.2 (6.4) | 86.4 (4.0) | 12.9 (0.1) | 79.7 (24.3) | ||