TABLE 3.
Efflux of antibacterial compounds by the MexMN efflux pump of P. aeruginosa
| Compounda | MIC (μg/ml) |
|||||
|---|---|---|---|---|---|---|
| NB52019 PAO1 |
NB52021 ΔmexB |
NB52019-CDK0005 PA1438 (L172P) |
NB52019-CDK0006 PA1438 (L172P) ΔmexB |
NB52019-CDK0007 PA1438 (L172P) ΔmexN |
NB52019-CDK0008 PA1438 (L172P) ΔmexB ΔmexN |
|
| ATM | 4 | 0.25 | 8 | 8 | 4 | 0.25 |
| BAL30072 | 2 | 0.25 | 4 | 4 | 1 | 0.25 |
| Biapenem | 0.5 | 0.5 | 8 | 8 | 8 | 4 |
| CAR | 64 | 1 | 64–128 | 32 | 64 | 1 |
| CMN | 4 | 0.25 | 16 | 16 | 4 | 0.25 |
| FEP | 2 | 1 | 2 | 1 | 2 | 1 |
| CAZ | 2 | 0.5–1 | 4 | 4 | 1 | 0.5 |
| CFT | 0.5 | 0.5 | 1 | 1 | 0.5 | 0.5 |
| IPM | 1 | 1 | 8 | 8 | 8 | 8 |
| MEM | 1 | 0.25 | 4 | 2 | 4 | 1 |
| MET | >256 | 64 | >256 | 128 | >256 | 64 |
| NXL-105 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 |
| MOX | 32 | 8 | 64 | 32 | 32 | 8 |
| PIP | 4 | 0.5 | 4 | 1 | 4 | 0.5 |
| SUL | >256 | 64 | >256 | >256 | >256 | 64 |
| TAZ | >1024 | 128 | >1,024 | 1,024 | >1,024 | 128 |
| TIC | 16 | 0.5 | 32 | 8 | 16 | 0.5 |
| TMC | 512 | ≤2 | 512 | 128 | 512 | ≤2 |
| AZM | 128 | 256 | 128 | 128 | 128 | 128 |
| CHL | 32 | 8 | 32 | 8 | 32 | 8 |
| CIP | 0.25 | 0.125 | 0.25 | 0.125 | 0.25 | 0.125 |
| NOV | 1024 | 128 | 1,024 | 256 | 2,048 | 64 |
| NAL | 128 | 16 | 64 | 16 | 128 | 16 |
| GEN | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.5 |
| LVX | 0.5 | 0.25 | 0.25 | 0.25 | 0.5 | 0.125 |
| TET | 32 | 32 | 32 | 32 | 64 | 32 |
| TOB | 0.5 | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 |
a
ATM, aztreonam; AZM, azithromycin; CAR, carbenicillin; CHL, chloramphenicol; CIP, ciprofloxacin; CMN, carumonam; FEP, cefepime; CAZ, ceftazidime; CFT, ceftolozane; GEN, gentamicin; IPM, imipenem; LVX, levofloxacin; MEM, meropenem; MET, methicillin; MOX, moxalactam; NAL, nalidixic acid; NOV, novobiocin; PIP, piperacillin; SUL, sulbenicillin; TET, tetracycline; TIC, ticarcillin; TMC, temocillin; TOB, tobramycin.