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MexMN is functionally linked to the OprM outer membrane channel
| Strain | MIC (μg/ml) |
|||
|---|---|---|---|---|
| CAR | ATM | CMN | LVXa | |
| NB52019-CDK0005 PA1438L172P | 64 | 16 | 16 | 0.5 |
| NB52019-CDK0006 PA1428L172P ΔmexB | 32 | 8 | 16 | 0.25 |
| NB52019-CDK0032 PA1438L172P ΔoprM | 2 | 0.5 | 0.5 | ≤0.031 |
Note that LVX is also pumped by MexXY-OprM. Therefore, susceptibility to this antibiotic will also increase more when oprM is deleted than when mexB is deleted.
