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. 2019 Jan 29;63(2):e01957-18. doi: 10.1128/AAC.01957-18

TABLE 3.

Secondary pharmacokinetic parameters derived from individual estimates of Table 2 parametersa

Patient ID or statistical parameter CMS
 Colistin
AUCCMS
(h·mg/liter)		 Fe CMS CLtot CMS
(liters/h)		 CLCVVHD CMS
(liters/h)		 t1/2 CMS
(h)		 CSS min CMS
(mg/liter)		 Cssav CMS
(mg/liter)		 AUCCol
(h·mg/liter)		 Fe col CLtot col
(liters/h)		 CLCVVHD col
(liters/h)		 t1/2 Col
(h)		 CSS min col
(mg/liter)		 Cssav Col
(mg/liter)
1* 865 0.393 3.850 1.513 2.20 1.26 5.15 506 0.203 3.993 0.811 6.16 2.58 3.01
2* 181 0.163 8.766 1.429 2.24 0.58 2.26 404 0.230 3.283 0.755 14.57 4.63 5.05
3* 658 0.434 4.265 1.851 1.91 0.86 4.65 548 0.348 2.899 1.009 20.29 3.69 3.87
4 (406) 0.484 3.840 1.859 1.61 (0.34) (3.44) (251) 0.338 3.204 1.083 18.48 (1.91) (2.13)
5 (621) 0.424 4.183 1.774b 1.98 (0.62) (3.16) (480) 0.299 3.124 0.934b 16.26 (2.28) (2.44)
6* 479 0.361 4.889 1.765b 2.10 0.83 4.05 590 0.370 2.534 0.938b 18.47 4.64 5.00
7 (312) 0.459 2.996 1.375 1.85 (0.58) (4.41) (163) 0.163 3.110 0.507 15.79 (1.87) (2.30)
8* 1,044 0.511 2.990 1.528 2.24 1.60 6.63 607 0.329 2.511 0.826 34.12 3.92 3.85
10 (608) 0.290 3.933 1.141 1.78 (0.51) (3.36) (361) 0.128 4.702 0.602 10.78 (1.75) (1.99)
11* 765 0.574 2.651 1.522 3.50 2.41 7.47 741 0.430 1.164 0.501 23.21 4.00 7.24
Mean 665 0.409 4.236 1.576 2.14 1.26 5.03 566 0.284 3.052 0.796 17.81 3.91 4.67
SD 304 0.117 1.731 0.222 0.52 0.67 1.86 112 0.098 0.933 0.194 7.48 0.76 1.48
Median 712 0.429 3.892 1.525 2.04 1.06 4.90 569 0.314 3.117 0.804 17.37 3.96 4.43
Min 181 0.163 2.651 1.141 1.61 0.58 2.26 404 0.128 1.164 0.501 6.16 2.58 3.01
Max 1,044 0.574 8.766 1.859 3.50 2.41 7.47 741 0.430 4.702 1.083 34.12 4.64 7.24
Gmean 583 0.390 4.003 1.559 2.09 1.12 4.70 557 0.266 2.894 0.771 16.35 3.84 4.49
CV (%) 52 30 43 14 25 60 40 20 37 32 25 46 20 33
a

Parameters included cumulative areas under curve (AUC), fractions excreted through CRRT (Fe), total clearances (CLtot), and trough concentrations at steady-state (Css min) and average concentrations at steady-state (Cssav) of CMS and colistin. For dose-dependent parameters (AUC and CSS min), means, SD, medians, and ranges were calculated only with data from patients receiving a maintenance regimen of 3 MU every 8 h (indicated by asterisks) excluding the values in parentheses.

b

CLCVVHDF.