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A. ccRCC grouped by evolutionary subtypes: BAP1 driven (only BAP1 negative), PBRM1- > SCNA and PBRM1- > PI3K (only PBRM1 negative), Multiple clonal drivers (≥2 BAP1, SETD2 or PBRM1 negative), VHL monodriver/wildtype and other (PBRM1, BAP1 and SETD2 positive as well as only SETD2 negative). PBRM1 and SETD2 negative tumors were assigned to both multiple clonal drivers and PBRM1- > SETD2 subtype (gray arrow). B. Distribution of tumor grade, tumor stage and overall survival per subtype.
