Table 2.
Expression frequencies of PBRM1, BAP1 and H3K36me3 in relation to tumor stage and ISUP grade in ccRCC.
| pT1/pT2 n (%) |
pT3/pT4 n (%) |
P-value | Grade 1/2 n (%) |
Grade 3 n (%) |
Grade 4 n (%) |
P-value | |
|---|---|---|---|---|---|---|---|
| BAP1 | |||||||
| Negative | 93 (34.2) | 98 (50) | <0.0001 | 55 (29.1) | 66 (45.2) | 71 (51.1) | <0.0001 |
| Weak | 119 (43.7) | 81 (41.3) | 77 (40.7) | 65 (44.5) | 61 (43.9) | ||
| Strong | 60 (22.1) | 17 (8.7) | 57 (30.2) | 15 (10.3) | 7 (5) | ||
| Total | 272 | 196 | 189 | 146 | 139 | ||
| H3K36me3 | |||||||
| Negative | 104 (39.4) | 115 (59) | <0.0001 | 55 (30.5) | 66 (52.1) | 89 (64) | <0.0001 |
| Weak | 71 (26.9) | 47 (24.1) | 52 (28.9) | 44 (30.1) | 25 (18) | ||
| Strong | 89 (33.7) | 33 (16.9) | 73 (40.6) | 26 (17.8) | 25 (18) | ||
| Total | 264 | 195 | 180 | 146 | 139 | ||
| PBRM1 | |||||||
| Negative | 151 (59) | 150 (81.5) | <0.0001 | 92 (53.2) | 98 (71) | 113 (83.7) | <0.0001 |
| Weak | 67 (26.2) | 25 (13.6) | 48 (27.7) | 30 (21.7) | 18 (13.3) | ||
| Strong | 38 (14.8) | 9 (4.9) | 33 (19.1) | 10 (7.2) | 4 (3) | ||
| Total | 256 | 184 | 173 | 138 | 135 |