Table 3.
PBRM1, BAP1 and H3K36me3 Expression and Presence of Necrosis and Tumor Infiltrating Lymphocytes in ccRCC
| Necrosis n (%) |
P-value | Tumor Infiltrating Lymphocytes n (%) |
|||||
|---|---|---|---|---|---|---|---|
| Absent | Present | Sparse | Moderate | Dense | P-value | ||
| BAP1 | |||||||
| Negative | 130 (38.6) | 61 (44.5) | 0.0023 | 25 (36.8) | 93 (39.7) | 73 (42.4) | 0.0162 |
| Weak | 138 (40.9) | 66 (48.2) | 23 (33.8) | 101 (43.2) | 80 (46.5) | ||
| Strong | 69 (20.5) | 10 (7.3) | 20 (29.4) | 40 (17.1) | 19 (11) | ||
| Total | 337 | 137 | 68 | 234 | 172 | ||
| H3K36me3 | |||||||
| Negative | 139 (42) | 81 (60.5) | 0.0014 | 27 (40.3) | 113 (47.2) | 88 (50.3) | ns |
| Weak | 94 (28.4) | 27 (20.1) | 18 (26.9) | 89 (29.3) | 71 (21.3) | ||
| Strong | 98 (29.6) | 26 (19.4) | 22 (32.8) | 28 (23.6) | 12 (28.4) | ||
| Total | 331 | 134 | 67 | 229 | 169 | ||
| PBRM1 | |||||||
| Negative | 198 (62.7) | 105 (80.8) | 0.0009 | 31 (51.7) | 148 (67.6) | 124 (74.3) | 0.001 |
| Weak | 80 (25.3) | 16 (12.3) | 16 (26.7) | 44 (20.1) | 36 (21.6) | ||
| Strong | 38 (12) | 9 (6.9) | 13 (21.7) | 27 (12.3) | 7 (4.2) | ||
| Total | 316 | 130 | 60 | 219 | 167 | ||