Figure 4. Kidney function evaluation of streptozotocin (STZ)‐induced diabetic rats.

Diabetic rats were inducted by a single intraperitoneal injection of STZ in citrate buffer (60 mg/kg body weight). Serum creatinine (A) and blood urea nitrogen (B) were measured in normal (control) and STZ‐injected rats (2 weeks after STZ injection when plasma microparticles were assessed). Although the measured values of serum creatinine and blood urea nitrogen in STZ rats were slightly higher than those in normal rats, they remained within the normal range. Data are presented as individual values and the means ± SD, with N = 7 per group (non‐parametric Mann‐Whitney test, two‐tailed).