Figure 7. Increased circulating MPs disseminate inflammation through systemic circulation.

A, images of representative rat venules from three groups of studies. B, results summary showing that transfusion of diabetic plasma into a normal rat caused increased microvessel permeability (top graph) and leukocyte adhesion (lower graph) in the recipient rat (middle image, N = 6), and no significant changes occurred with transfusion of plasma from a normal donor rat (left image, N = 4). Removal of MPs from diabetic plasma abolished its effect on leukocyte adhesion and slightly attenuated the increased permeability (right image, N = 5). ^* P < 0.05; ^** P ≤ 0.001; NS, P > 0.1.