Table 3.
Baseline respiratory parameters in anaesthetized wild‐type and mdx mice before and during peak sustained efforts during airway occlusion
| Wild‐type (n = 10) | mdx (n = 10) | ||||
|---|---|---|---|---|---|
| Baseline | Obstruction | Baseline | Obstruction | P (RM two‐way ANOVA) | |
| f R (breaths min−1) | 217 ± 34 | 76 ± 18 | 227 ± 41 | 109 ± 32 | Obstruction: P < 0.0001; Gene: P = 0.0802; Obstruction × Gene: P = 0.1962 |
| (%) | 95.1 ± 2.1 | 40.1 ± 9.5 | 95.8 ± 1.9 | 46.3 ± 9.1 | Obstruction: P < 0.0001; Gene: P = 0.116; Obstruction × Gene: P = 0.2132 |
| T i (ms) | 105 ± 15 | 144 ± 18 | 88 ± 14* | 135 ± 15 | Obstruction: P < 0.0001; Gene: P = 0.0441; Obstruction × Gene: P = 0.2073 |
| TTP (ms) | 58 ± 15 | 76 ± 11 | 50 ± 10 | 82 ± 13 | Obstruction: P < 0.0001; Gene: P = 0.7911; Obstruction × Gene: P = 0.0438 |
| Dia AUC (A.U.) | 101 ± 76 | 585 ± 241 | 57 ± 56 | 382 ± 242$ | Obstruction: P < 0.0001; Gene: P = 0.0582; Obstruction × Gene: P = 0.1349 |
| T3 EIC AUC (A.U.) | 65 ± 28 | 594 ± 215 | 34 ± 24 | 198 ± 131$$$ | Obstruction: P < 0.0001; Gene: P < 0.0001; Obstruction × Gene: P = 0.0001 |
f R, respiratory frequency; , peripheral capillary oxygen saturation; T i, inspiratory duration; TTP, time to peak sub‐atmospheric pressure; Dia AUC, area under the curve of diaphragm integrated EMG signal (A.U. = arbitrary units); T3 EIC AUC, area under the curve of T3 external intercostal integrated EMG signal (A.U. = arbitrary units). Data are shown as the mean ± SD and were statistically compared by repeated measures two‐way analysis of variance (RMANOVA).
* P < 0.05 compared to wild‐type baseline,
$ P < 0.05,
$$$ P < 0.001 compared to wild‐type obstruction.