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. 2018 Dec 5;39:59–68. doi: 10.1016/j.ebiom.2018.11.056

Fig. 2.

Fig. 2

Forced expression of HO-1 improves heart function. The systemic HO-1 transgenic overexpression aged mice were 16 months. (a) Overexpression of HO-1 was detected by western blot. n = 4. **P < .05. Data are mean ± SEM; Two-tailed t-test was used for the statistical analysis. (b) Representative short-axis M-mode images from Young, Old and Old (HO-1) group. (c) Ejection Fraction (EF) and Fractional Shortening (FS) of Young, Old and Old (HO-1) group were detected by Echocardiographic assessment. n = 7. **P < .05. Data are mean ± SEM; Two-tailed t-test was used for the statistical analysis. (d) Relative mRNA levels of Col 1α1and Col 3α1 analyzed by qRT-PCR. n = 4. *P < .01, **P < .05. Data are mean ± SEM; Two-tailed t-test was used for the statistical analysis. (e) Masson staining detected the deposition of ECM. Scale bars represent 50 μm. n = 3.