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. 2019 Jan 25;10:432. doi: 10.3389/fnagi.2018.00432

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Copyright © 2019 Witek, Hickman, Lahiri and Srinivasan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry of hippocampus of mouse induced neuroinflammation. Shows representative IHC section stained for Iba+ microglia (A,B), glial fibrillary acidic protein (GFAP)+ astrocytes (C,D), nuclear factor-kappa B (NF-κB) p65+ (E,F) and GLIZ+ cells (G,H) in the hippocampus of mouse subjected to lipopolysaccharide (LPS) induced neuroinflammation and vehicle treated mouse as indicated. Panel (I) shows the mean staining area of the 3,3′-diaminobenzidine (DAB)-positive cells depicting microglia, astrocytes, NF-κB p65 or GILZ+ cells in groups of mice induced neuroinflammation or vehicle treated mice (DG, dentate gyrus; CA 1, Cornu Ammonis 1; and CA 3, Cornu Ammonis 3; representing specific regions of the hippocampus). *p < 0.05 as compared with vehicle treated mice.