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. 2019 Jan 25;9:776. doi: 10.3389/fpsyt.2018.00776

Figure 3.

Figure 3

Upregulation of proBDNF and its signaling in rats with anxiety-like phenotype and rats with depression-like phenotype. (A) Representative Western blot, and (B) semi-quantitative analyses of mature BDNF, proBDNF, proBDNF/ BDNF, p75NTR, and sortilin in the hippocampus of rats with depression-like and anxiety-like phenotype. Note that the expression of proBDNF was increased significantly in the rats with depression-like phenotype and the rats with anxiety-like phenotype. (C) Immunohistochemistry of proBDNF in the hippocampus of rats with depression-like and anxiety-like behaviors. Note that intensive proBDNF was expressed in the hippocampus of the CRS rats and CFA rats. Bar = 100 μm. *p < 0.05, **p < 0.01, vs. control group (one-way ANOVA). All of the data are presented as mean ±SEM.