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. 2019 Jan 25;10:12. doi: 10.3389/fphys.2019.00012

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Copyright © 2019 Heuser, Frings-Meuthen, Rittweger and Galer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean δ^44/42Ca_urine (±1SD) of the BDC (BDC-6 and BDC-2) phase of each subject plotted against the average excreted Ca per 24 h (±1SD). A significant logarithmic correlation exists that is statistically significant (r² = 0.884, P < 0.001; white dashed line). Such a correlation is typical for Rayleigh-type fractionation such as might be expected during generation of secondary urine in the kidneys. These data were collected before and after the head-down-tilt bed rest period. The gray shaded area represents the 95% confidence band of the logarithmic regression trend.