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. 2019 Jan 25;10:12. doi: 10.3389/fphys.2019.00012

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Copyright © 2019 Heuser, Frings-Meuthen, Rittweger and Galer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Boxplot of changes in urinary Ca isotopic composition obtained during our study. For comparison, the data of Skulan et al. (2007); Morgan et al. (2012), and Channon et al. (2015) are also shown. Overall, the changes observed in the study are in good agreement with those found in previous studies. A small but statistically insignificant difference between the control group (C) and the KHCO₃ supplemented group (S) can be seen. Letters for the Skulan et al. dataset correspond to: (C) control group, (E) exercise group, and (A) alendronate supplemented group.