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. 2019 Jan 25;10:12. doi: 10.3389/fphys.2019.00012

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Copyright © 2019 Heuser, Frings-Meuthen, Rittweger and Galer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Log-log plot of ⁴⁴Ca/⁴²Ca in urine versus daily-excreted Ca (mmol/d) for the pre-bed rest BDC data (BDC-6 and BDC-2, yellow squares) and directly after the bed rest phase (R + 0, R + 2, and R + 5, green diamonds). Both sets of data show negative correlations with trend lines indicated (BDC, gray; R + 0, black dashed), with the after bed rest data shifted systematically toward lower ⁴⁴Ca/⁴²Ca, i.e., more negative δ^44/42Ca. This vertical offset likely reflects bone loss during bed rest independent of changes arising from variable renal Ca reabsorption in the kidneys.