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. 2019 Jan 31;9:1081. doi: 10.1038/s41598-018-37155-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic depiction of CERONCO’s cytokinetic decision calculator. The calculator dictates the transitions between cell states, which are determined by corresponding model parameters (see Table 1) with a time step of 1 h. It incorporates: cycling of proliferating cells through the successive cell cycle phases; symmetric and asymmetric modes of stem cell division; terminal differentiation of committed progenitor cells after a number of mitotic divisions; transition of proliferating cells to the dormant phase due to inadequate supply of oxygen and nutrients; reentering of dormant G0 cells into the active cell cycle due to local restoration of oxygen and nutrient supplies, spontaneous apoptosis, necrosis of inadequately nourished tumour cells, irradiation-induced cell death through necrosis, chemotherapy induced cell death through apoptosis. LIMP: Limited Mitotic Potential cells. DIFF: Terminally differentiated cells. G1: Gap 1 phase. S: DNA synthesis phase. G2: Gap 2 phase. M: Mitosis. G0: dormant phase. Hit: cells lethally hit by irradiation/drug.