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. 2019 Jan 31;9:1081. doi: 10.1038/s41598-018-37155-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predictive tests with patients 55, 68, 71. Left panel: GF = 10%, HF = 30%, DF = 5%. Right panel: GF = 60%, HF = 30%, DF = 5%. Tumour volume time course for patients 55 (1st row), 68 (2nd row) and 71 (3rd row) using the mean value sets of the other two patients. 0: pre-therapy timepoint. The error bars indicate the permitted variability around the clinical VRP value according to the criterion VRP 10 (equation (11)) for the time points pre-therapy, midterm, BT0, BT1, BT2 successively. This variability is introduced to reflect possible tumour delineation errors.