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. 2019 Jan 31;9:1099. doi: 10.1038/s41598-018-37715-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison analysis of canonical signaling pathways temporally activated in neurons during prion infection. Heat map showing top activated canonical pathways generated using genes with expression enriched in neurons during prion infections. Upregulated pathways are shaded orange, down-regulated pathways are shaded blue. The intensity indicates the degree that each gene was up-regulated or down-regulated as determined by the IPA determined z-score.