Table 3.
Neuron-enriched genes that showed increased levels during late stages of disease.
| Gene Symbol | Gene Name | Biological function (representative GO terms) |
|---|---|---|
| RAB6B | RAB6B, member RAS oncogene family | small GTPase mediated signal transduction; protein transport; vesicle-mediated transport |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | negative regulation of neuron projection development; regulation of small GTPase mediated signal transduction |
| RBFOX2 | RNA binding protein, fox-1 homolog 2 | RNA splicing; radial glia guided migration of Purkinje cell; dendrite morphogenesis |
| STAC3 | SH3 and cysteine rich domain 3 | neuromuscular synaptic transmission; intracellular signal transduction |
| SOX11 | SRY (sex determining region Y)-box 11 | negative regulation of transcription; nervous system development; positive regulation of cell proliferation; glial cell development |
| CTNND2 | catenin (cadherin associated protein), delta 2 | regulation of transcription, regulation of synaptic plasticity; synapse organization; dendritic spine morphogenesis, |
| CBLN2 | cerebellin 2 precursor protein | positive regulation of synapse assembly |
| COX6A2 | cytochrome c oxidase subunit VIa polypeptide 2 | mitochondrial electron transport, cytochrome c to oxygen |
| CISH | cytokine inducible SH2-containing protein | negative regulation of protein kinase activity; protein kinase C-activating G-protein coupled receptor signaling pathway; protein ubiquitination; cytokine-mediated signaling pathway; regulation of growth |
| FOXO6 | forkhead box O6 | regulation of transcription; memory; positive regulation of dendritic spine development |
| FZD9 | frizzled class receptor 9 | cell surface receptor signaling pathway; learning or memory, Wnt signaling pathway; positive regulation of neural precursor cell proliferation |
| KIF21B | kinesin family member 21B | microtubule-based movement |
| RXRG | retinoid X receptor gamma | regulation of transcription; regulation of myelination; retinoic acid receptor signaling pathway |
| SLC7A3 | solute carrier family 7 (cationic amino acid transporter, y + system), member 3 | amino acid transmembrane transport |
| TENM3 | teneurin transmembrane protein 3 | cell morphogenesis; cell adhesion; positive regulation of neuron projection development; cell differentiation, |
| SLA | Src like adaptor | cell differentiation; innate immune response; |
| DNAJB12 | DNAJ heat shock protein family (Hsp40) member B12 | NRF2-mediated Oxidative Stress Response; Protein Ubiquitination Pathway |
| HSPB3 | Heat-shock protein family B (small) member 3 | response to unfolded protein |
| FAM110D | Family with sequence similarity 110 member D |