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. 2019 Jan 31;9:1013. doi: 10.1038/s41598-018-37665-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibitory effects of fig latex on Ki67 proliferation protein marker on cervical cancer cells. Following treatment with 0.125 μg/ml of latex for 48 hours, the level of ki67 protein expression in HaCaT cells did not change significantly. In contrast, level of ki67 expression was downregulated significantly in treated cervical cancer cell lines. This suggests the selective inhibitory effect of fig latex on expression of Ki67 in HPV positive cells.