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. 2018 Mar 5;16(2):165–177. doi: 10.1038/cmi.2017.167

Figure 2.

Figure 2

LEC-specific NIK deletion reduces the number of B cells in LNs. (a, b) Representative images (a) and total cell number (b) of spleen, iLNs, mLNs and cLNs of WT and NIKLEC-KO (KO) mice. (c) Flow cytometry analysis of the frequency and absolute cell number of T cells (CD3+) and B cells (B220+) in the spleen, iLN, mLN and cLN of WT and NIKLEC-KO (KO) mice. Data are presented as representative plots (upper panel) and summary graphs (lower panel). Data are representative of at least three independent experiments and are presented as means±s.e.m. *P<0.05; **P<0.01; ***P<0.001. cLN, cervical lymph node; DC, dendritic cell; iLN, inguinal lymph node; KO, knockout; LEC, lymphatic endothelial cell; LN, lymph node; mLN, mesenteric lymph node; NIK, nuclear factor-κB-inducing kinase; NS, not significant, WT, wild type.