Table 3.

Self-reported Adherence and Adverse Events^a Associated With Antibiotics Used in the Sequential Treatment Regimens

	Doxycyclineb	Azithromycin	Sitafloxacinc
Adherence	n = 217d	n = 63	n = 152
Took all doses	195 (89.9)	63 (100)	138 (90.8)
Missed 1–4 doses	18 (8.3)	0	10 (6.6)
Missed >4 doses	4 (1.8)	0	4 (2.6)
Adverse events	n = 224d	n = 70	n = 154
None reported	194 (86.6)	64 (91.4)	124 (80.5)
Nausea	12 (5.4)	4 (5.7)	5 (3.2)
Vomiting	2 (0.9)	0	1 (0.6)
Diarrhea	11 (4.9)	2 (2.9)	18 (11.7)
Rash/sunburne	6 (2.7)	0	1 (0.6)
Tendon/joint pain	0	0	8 (5.2)
Headache or dizziness	3 (1.3)	0	2 (1.3)

Data are presented as No. (%) unless otherwise indicated.

^aAdverse events were only grade 1 (no interference with daily activities and no treatment required) or grade 2 (minor interference with daily activities or required minor treatment).

^bGrade 2 events were vomiting (n = 1), diarrhea (n = 2), rash (n = 1). All others were grade 1.

^cGrade 2 events were diarrhea (n = 5), tendinitis (n = 1), self-limiting hypoesthesia (n = 1). All others were grade 1.

^dThe total receiving each drug was doxycycline, n = 244; azithromycin, n = 77; sitafloxacin, n = 167. Individuals with no data on adherence or adverse events were excluded from those analyses.

^eSunburn (n = 5) and rash (n = 1).