Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 5;16(2):154–164. doi: 10.1038/cmi.2017.160

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

PMC Copyright notice

Missense mutations of Siglece coding region in B6.NZM ^{Sle1/Sle2/Sle3} mice. (a) Sequencing reads were aligned using CLC Main Workbench. Arrows indicate SNP annotations. (b) Sequence alignment of Siglec E from C57BL/6 (WT) and B6.NZM ^{Sle1/Sle2/Sle3} (Sle1–3) mice. Red indicates amino-acid substitutions. (c) Graphical representation of the Siglec E protein, which consists of a leader sequence (LS), a V-set Ig-like domain, C2-set Ig-like-1 and C2-set Ig-like-2 domains, a transmembrane domain (TM) and a cytoplasmic domain. Two amino-acid substitutions were in the V-set Ig-like domain, at positions 24 and 102, and one amino-acid substitution was in the C2-set Ig-like-1 domain at position 227. Siglec, sialic acid-binding immunoglobulin-like lectin; SNP, single-nucleotide polymorphism; WT, wild type.