Figure 7.

Targeted mutation of Siglece increases macrophage responses to HMGB1, as indicated by increased production of TNF-α (a) and IL-6 (b). Data shown indicate means and s.e.m. from a representative experiment with three mice per group and were reproduced twice. P-values were determined by two-tailed Student’s t-test. Errors bar show deviations in biological repeats. HMGB1, high mobility group box 1; IL, interleukin; PBS, phosphate-buffered saline; TNF-α, tumor necrosis factor-α; WT, wild type.