Table 1.
Meta-analysis results for top 8 loci in the SIGLEC region associated with SLE in Asian human cohorts
| Chr. | Position hg19 | SNP | Ref/Alt | MAF | Location | OR Korean | OR Han Chinese | OR Malaysian Chinese | P-value Meta-analysis | eQTL |
|---|---|---|---|---|---|---|---|---|---|---|
| 19 | 52011292 | Rs9676266 | C/A | 0.10(A) | Intergenic | 1.3 | 1.14 | 1.44 | 9.27E−06 | No |
| 19 | 52011329 | Rs9676272 | C/A | 0.13(A) | Intergenic | 1.3 | 1.15 | 1.39 | 8.96E−06 | No |
| 19 | 52011598 | Rs13343377 | C/A | 0.26(A) | Intergenic | 1.32 | 1.16 | 1.23 | 1.31E−06 | No |
| 19 | 52018474 | Rs6509546 | G/A | 0.25(A) | Intergenic | 1.32 | 1.15 | 1.17 | 1.26E−06 | No |
| 19 | 52025247 | Rs2124910 | T/C | 0.43(T) | Intron | 0.83 | 0.89 | 0.87 | 4.62E−06 | eQTL for SIGLEC12 |
| 19 | 52031648 | Rs10419617 | A/G | 0.40(A) | Synonymous | 0.83 | 0.89 | 0.91 | 9.09E−06 | eQTL for SIGLEC12 |
| 19 | 52033742 | Rs2305772 | G/A | 0.42(G) | Intron | 0.83 | 0.88 | 0.91 | 8.84E−06 | eQTL for SIGLEC12 |
| 19 | 52035059 | Rs12609761 | A/C | 0.15(C) | 5′-UTR variant | 1.29 | 1.18 | 1.35 | 8.44E−06 | No |
Abbreviations: Chr., chromosome; eQTL, expression quantitative trait loci; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism; UTR, untranslated region.