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. 2019 Jan 31;9:1060. doi: 10.1038/s41598-018-37658-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of two mediation models: Model (A) tests for the indirect effects of hippocampal mediator variables on the direct effect of age on the fornix (path c’). The indirect effect is the product a*b of the correlations between age and hippocampus (path a) and the partial correlation between hippocampus and fornix accounting for age (path b). Model (B) tests the indirect effects of the fornix mediator variables on the direct effect of age on the hippocampus.