Table 3.

Distribution and comparison of methylation markers by sample type.

Biomarker	Geometric mean (95% Confidence interval)			Ratio of geometric means(95% confidence interval); P-Valuea
	Neoplastic (n = 113)	Matched non-neoplastic(n = 113)	Control (n = 343)	Neoplastic vs. control	Non-neoplasticvs. control
sFRP2	22.1 (19.7, 24.9)	14.0 (12.8, 15.4)	14.1 (13.4, 14.9)	1.57 (1.40, 1.76)	0.99 (0.89, 1.11)
	(n = 105)	(n = 106)	(n = 303)	P < 0.0001	P = 0.92
sFRP4	44.7 (42.1, 47.5)	34.4 (31.8, 37.2)	32.0 (31.0, 33.1)	1.40 (1.31, 1.49)	1.07 (1.00, 1.15)
	(n = 108)	(n = 109)	(n = 312)	P < 0.0001	P = 0.057
WIF1	21.6 (18.6, 25.2)	12.8 (11.1, 14.8)	13.9 (12.8, 15.0)	1.56 (1.33, 1.83)	0.93 (0.79, 1.08)
	(n = 104)	(n = 105)	(n = 292)	P < 0.0001	P = 0.33
APC1A	2.92 (2.37, 3.60)	2.54 (2.16, 3.00)	1.99 (1.83, 2.17)	1.47 (1.22, 1.77)	1.28 (1.07, 1.52)
	(n = 102)	(n = 102)	(n = 297)	P = 0.0001	P = 0.006
APC2	35.4 (32.1, 39.0)	22.3 (20.4, 24.4)	20.2 (18.9, 21.5)	1.76 (1.55, 1.99)	1.11 (0.98, 1.26)
	(n = 111)	(n = 106)	(n = 322)	P < 0.0001	P = 0.12
sFRP1	35.7 (30.5, 41.9)	24.1 (21.7, 26.7)	25.1 (23.2, 27.1)	1.42 (1.21, 1.67)	0.96 (0.82, 1.13)
	(n = 39)	(n = 29)	(n = 118)	P < 0.0001	P = 0.62
sFRP5	7.14 (5.75, 8.87)	4.90 (4.08, 5.90)	6.40 (5.64, 7.27)	1.12 (0.87, 1.43)	0.77 (0.60, 0.98)
	(n = 102)	(n = 95)	(n = 275)	P = 0.38	P = 0.03
MINT1	4.14 (3.32, 5.16)	3.40 (2.87, 4.04)	3.13 (2.82, 3.48)	1.32 (1.06, 1.64)	1.09 (0.89, 1.33)
	(n = 73)	(n = 70)	(n = 200)	P = 0.012	P = 0.42
RUNX3	8.73 (7.15, 10.7)	7.58 (6.37, 9.02)	7.44 (6.68, 8.29)	1.17 (0.94, 1.46)	1.02 (0.83, 1.25)
	(n = 87)	(n = 97)	(n = 248)	P = 0.15	P = 0.86
SOX7	5.70 (4.60, 7.06)	3.92 (3.41, 4.51)	5.41 (4.88, 5.99)	1.05 (0.85, 1.30)	0.73 (0.60, 0.87)
	(n = 100)	(n = 106)	(n = 280)	P = 0.63	P = 0.001
TUBB6	12.2 (10.5, 14.2)	8.04 (6.93, 9.34)	9.34 (8.52, 10.23)	1.31 (1.10, 1.56)	0.86 (0.72, 1.03)
	(n = 108)	(n = 95)	(n = 292)	P = 0.003	P = 0.11

^aComputed from a 2-sample t-test on log transformed data.