Fig. 4.

Docking binding mode of X-ray ligands (Table 2, yellow), BPA (green) and BPAF (magenta) in the ligandbinding sites of the estrogen receptor (a)(agonist-bound conformation; gray), glucocorticoid receptor (b)(antagonist-bound conformation; cyan), PXR (c)(agonist-bound conformation; orange), FXR (d)(agonist-bound conformation; green), and FXR (e)(antagonist-bound conformation; brown). The ligand is shown as a stick model, colored according to the atom types (blue, N; red, O; orange, S; green, Cl). For clarity, only the protein amino acids that form hydrogen bonds with the ligands are shown as sticks. Hydrogen bonds are indicated by black dotted lines.