Fig. 3.

Alterations in generalised fractional anisotropy in white matter tracts. a) gFA associated with the white matter tracts in bilateral cingulum, column and body of fornix, superior longitudinal fasciculus, and the parts of cortico-thalamic radiations terminating in the precentral gyrus are aberrant for a wide range of thresholds in connectometry analysis. These tracts are shown overlaid on the brain schematic in different views. Tracts are color coded in accordance with their t-scores where the warmer color for higher positive t-score indicates a reduced gFA in patients and the cooler color for lower negative t-score indicates increased gFA associated with the tracts in patients compared to controls. b) The comparison of mean gFA across the tracts between patients and controls for each aberrant region is shown in the box plot. The p-value for each region is indicated by stars in grey (double star for p < 0.005 and single star for 0.005 < p < 0.05) along with the effect sizes (d-scores). c) The white region in the two-dimensional panels depict the threshold values for which the micro-structural alterations are significantly different in connectometry analysis. Stars in red/blue represent exemplary threshold values of t = 1.94 and tract length =30mm at which the results are shown in a) and b).