Table 4.
Summary of network metric results comparing patients with sickle-cell disease and anemic controls, controlling for the effects of age and sex.
| Betweenness centrality | ||||||
|---|---|---|---|---|---|---|
| ROI | Threshold | Variable | t(29) | p(FDR) | B | Interpretation |
| L_LC | 0.2 | Group | 3.17 | 0.005 | 10.06 | SCD ↑ AC ↓ |
| L_LC | 0.3 | Group | 2.95 | 0.006 | 6.421 | SCD ↑ AC ↓ |
| Strength | ||||||
| ROI | Threshold | Variable | t(28) | p(FDR) | B | Interpretation |
| R_LC | 0.5 | Group | 2.176 | 0.039 | 0.655 | SCD ↑ AC ↓ |
Groups: Sickle Cell Disease (SCD), AC (Anemic Controls).
ROIs: Left Locus Coeruleus (L_LC), Right Locus Coeruleus (R_LC).
Abbreviations: Betweenness Centrality (BWC).
Statistics: Network construction variable (Pearson's r vs Fisher transformed Z), Beta (B), t-value with 29 degrees of freedom (t(29)), Cohen's d (d), p-value corrected for false discovery rate p(FDR) < 0.05