Figure 2. Schematic of Rab11FIP regulation of trafficking in various cell contexts.

(A) Fibroblastic or cancer cells show Rab11FIP vesicles (red circles) tethered with actin (red lines) and myo5a, moving along microtubules (green) or tethered/moving along actin filaments carrying cargo such as integrins and growth factor receptors out in the tips of invasive pseudopods. (B) Neuronal cells use Rab11FIP to regulate transport along the axonal microtubules and at the tips of axonal growth cones in interaction with actin filaments. (C) Dividing cells use Rab11FIPs to control transport of polarity proteins along microtubules toward the midbody and this transport results in eventual lumen formation after division is complete and as polarised cysts form.