Figure 8. Schematic representation summarizing the interaction network of nuclear AKT and its predicted location at functional nuclear regions.

(1) AKT is translocated from the cytoplasm to the nucleus by an yet unknown mechanism; (2) cofilin bound to monomeric actin mediates the transport of actin to the nucleus; (3) In the nucleus, AKT interacts with actin/cofilin complex; (4) AKT interaction with actin/cofilin complex may be target to active Pol II phosphorylated in the CTD.