Table 1.
Vital signs.
| Saline |
GLP-1 |
Intervention effect |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | During infusion | p | T = 120 | p | Baseline | During infusion | p | T = 120 | p | Saline Δ | GLP-1 Δ | Estimate | p⁎ | |
| Heart rate (beats/min) | 53 ± 10 | 56 ± 10 | 0.02 | 56 ± 10 | 0.08 | 57 ± 10 | 64 ± 11 | 0.0004 | 63 ± 11 | 0.009 | 2.6 ± 4.7 | 6.7 ± 7.4 | 4.08 | 0.15 |
| sBP (mm Hg) | 129 ± 14 | 129 ± 13 | 0.35 | 131 ± 14 | 0.58 | 125 ± 11 | 136 ± 12 | 0.007 | 138 ± 13 | 0.02 | 1.9 ± 11.8 | 13.2 ± 16.5 | 11.3 | 0.07 |
| dBT (mm Hg) | 74 ± 10 | 74 ± 10 | 0.37 | 74 ± 8 | 0.86 | 75 ± 8 | 78 ± 9 | 0.18 | 75 ± 10 | 0.98 | −0.5 ± 9.9 | −0.2 ± 10.6 | 0.33 | 0.94 |
Data are means ± SD. Vital sign data in obese adults at baseline, on average throughout infusions and after 120 min of infusion of saline or glucagon-like peptide-1 (7–36). sBP, systolic blood pressure; dBP, diastolic blood pressure. Δ is change between baseline and timepoint 120 min.
⁎
Is comparison of change from baseline to time point 120 min, between saline and GLP-1 infusion.