Table 3. Genotype and allele frequencies of SNP loci in the case and control groups.
| Variable | Case group (n=400) | Control (n=400) | Crude OR (95%CI) | P-value | Adjusted OR (95%CI) | P-value |
|---|---|---|---|---|---|---|
| IL-6 rs1800795 | ||||||
| Genotype | ||||||
| GG | 258 (64.5%) | 278 (69.5%) | 1.00 | |||
| GC | 82 (20.5%) | 105 (26.3%) | 0.841 (0.594–1.193) | 0.312 | 0.911 (0.746–1.096) | 0.355 |
| CC | 60 (15.0%) | 17 (4.3%) | 3.803 (2.098–6.968) | <0.001 | 1.619 (1.358–1.832) | <0.001 |
| Dominant model | ||||||
| GG | 258 (64.5%) | 278 (69.5%) | 1.00 | |||
| GC+CC | 142 (35.5%) | 122 (30.5%) | 1.254 (0.923–1.704) | 0.133 | 1.117 (0.961–1.290) | 0.153 |
| Recessive model | ||||||
| GG+GC | 340 (85.0%) | 383 (95.8%) | 1.00 | |||
| CC | 60 (15.0%) | 17 (4.3%) | 3.976 (2.210–7.230) | <0.001 | 1.657 (1.396–1.866) | <0.001 |
| Alleles | ||||||
| G | 598 (74.8%) | 661 (82.6%) | 1.00 | |||
| C | 202 (25.3%) | 139 (17.4%) | 1.606 (1.251–2.063) | <0.001 | 1.247 (1.115–1.383) | <0.001 |
| IL-8 rs4073 | ||||||
| Genotype | ||||||
| TT | 101 (25.3%) | 117 (29.3%) | 1.00 | |||
| TA | 189 (47.3%) | 186 (46.5%) | 1.177 (0.831–1.668) | 0.339 | 1.088 (0.911–1.310) | 0.384 |
| AA | 110 (27.5%) | 97 (24.3%) | 1.314 (0.881–1.959) | 0.160 | 1.147 (0.938–1.401) | 0.191 |
| Dominant model | ||||||
| TT | 101 (25.3%) | 117 (29.3%) | 1.00 | |||
| TA+AA | 299 (74.7%) | 283 (70.7%) | 1.224 (0.885–1.692) | 0.204 | 1.109 (0.942–1.322) | 0.234 |
| Recessive model | ||||||
| TT+TA | 290 (72.5%) | 303 (75.8%) | 1.00 | |||
| AA | 110 (27.5%) | 97 (24.3%) | 1.185 (0.852–1.647) | 0.294 | 1.087 (0.922–1.264) | 0.333 |
| Alleles | ||||||
| T | 391 (48.9%) | 420 (52.5%) | 1.00 | |||
| A | 409 (51.1%) | 380 (47.5%) | 1.156 (0.946–1.414) | 0.147 | 1.075 (0.972–1.189) | 0.161 |
| MMP-13 rs2252070 | ||||||
| Genotype | ||||||
| GG | 149 (37.3%) | 195 (48.8%) | 1.00 | |||
| GA | 165 (41.3%) | 157 (39.3%) | 1.375 (1.002–1.889) | 0.041 | 1.183 (1.001–1.398) | 0.049 |
| AA | 86 (21.5%) | 48 (12.0%) | 2.345 (1.521–3.620) | <0.001 | 1.482 (1.226–1.754) | <0.001 |
| Dominant model | ||||||
| GG | 149 (37.3%) | 195 (48.8%) | 1.00 | |||
| GA+AA | 251 (62.8%) | 205 (51.3%) | 1.602 (1.197–2.146) | <0.001 | 1.271 (1.095–1.480) | 0.001 |
| Recessive model | ||||||
| GG+GA | 314 (78.5%) | 352 (88.0%) | 1.00 | |||
| AA | 86 (21.5%) | 48 (12.0%) | 2.008 (1.344–3.005) | <0.001 | 1.361 (1.151–1.569) | <0.001 |
| Alleles | ||||||
| G | 463 (57.9%) | 547 (68.4%) | 1.00 | |||
| A | 337 (42.1%) | 253 (31.6%) | 1.574 (1.276–1.942) | <0.001 | 1.246 (1.127–1.373) | <0.001 |