Table 4. Correlation between IL-6, IL-8, and MMP-13 SNPs and Kellgren–Lawrence grading in KOA patients.
| Variable | 2 (n=218) | 3 (n=101) | 4 (n=81) | P-value |
|---|---|---|---|---|
| IL-6 rs1800795 | ||||
| GG (n=258) | 153 (70.2%) | 81 (80.2%) | 24 (29.6%) | <0.001 |
| GC (n=82) | 48 (22.0%) | 14 (13.9%) | 20 (24.7%) | |
| CC (n=60) | 17 (7.8%) | 6 (5.9%) | 37 (45.7%) | |
| IL-8 rs4073 | ||||
| TT (n=101) | 64 (24.8%) | 21 (8.1%) | 16 (6.2%) | 0.186 |
| TA (n=189) | 98 (38.0%) | 54 (20.9%) | 37 (14.3%) | |
| AA (n=110) | 56 (21.7%) | 26 (10.1%) | 28 (10.9%) | |
| MMP-13 rs2252070 | ||||
| GG (n=149) | 110 (42.6%) | 28 (10.9%) | 11 (4.3%) | <0.001 |
| GA (n=165) | 102 (39.5%) | 39 (15.1%) | 24 (9.3%) | |
| AA (n=86) | 6 (2.3%) | 34 (13.2%) | 46 (17.8%) |