Table II. List of down-regulated testis-expressed proteins in spermatozoa of rs35033974hh homozygous men, as discovered by shotgun mass spectrometry and measured by SRM.
| UniProt accession | Gene name | Protein | Shotgun log2- fold change | SRM log2- fold change | Protein class |
|---|---|---|---|---|---|
| Q9BY14 | TEX101 | Testis-expressed protein 101 (isoform 1) | –4.8 | –4.2 | Cell-surface |
| Q17RY6 | LY6K | Lymphocyte antigen 6K (isoform 1) | –4.9 | –3.8 | Cell-surface |
| P10323 | ACR | Acrosin | –2.9 | –3.6 | Secreted |
| Q6X784 | ZPBP2 | Zona pellucida-binding protein 2 | –2.9 | –1.2 | Secreted |
| Q8IXA5 | SPACA3 | Sperm acrosome membrane-associated protein 3 | –2.6 | –2.1 | Cell-surface |
| Q5VZ72 | IZUMO3 | Izumo sperm–egg fusion protein 3 | –2.6 | –1.2 | Cell-surface |
| P38567 | SPAM1 | Hyaluronidase PH-20 | –2.6 | –3.3 | Secreted |
| Q8NEB7 | ACRBP | Acrosin-binding protein | –2.6 | –2.9 | Secreted |
| Q9UKF5 | ADAM29 | Disintegrin and metalloproteinase domain-containing protein 29 | –1.3 | –1.2 | Cell-surface |
| Q9H4B8 | DPEP3 | Dipeptidase 3 | –0.2 | 0.4 | Cell-surface |