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. 2018 Nov 19;18(2):352–371. doi: 10.1074/mcp.RA118.001181

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© 2019 Noto et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 10. — RABEP2 expression parallels the severity of gastric premalignant and malignant lesions in H. pylori-infected humans. A, RABEP2 expression was evaluated by immunohistochemistry in human populations at high risk for gastric cancer in Colombia and Chile. Gastric specimens from H. pylori-infected patients with nonatrophic gastritis, multifocal atrophic gastritis, intestinal metaplasia (premalignant) and gastric adenocarcinoma (malignant) were evaluated for RABEP2 immunostaining. Representative images are shown for nonatrophic gastritis, intestinal metaplasia, and gastric adenocarcinoma (200X and 400X magnification). B, A single pathologist assessed the percentage of epithelial RABEP2+ cells and the intensity of RABEP2 staining. The immunohistochemistry (IHC) score reflects the percentage of cells positive for RABEP2, multiplied by the intensity of staining, as previously described (22). Each bar indicates the average IHC score among patients with nonatrophic gastritis, multifocal atrophic gastritis or intestinal metaplasia (premalignant), or gastric adenocarcinoma (malignant) with standard error of the mean from the indicated number of patients evaluated. ANOVA tests were used to determine statistical significance among groups. ****; p < 0.0001.