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. 2018 Nov 19;18(2):352–371. doi: 10.1074/mcp.RA118.001181

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© 2019 Noto et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 11. — G3BP2 expression parallels the severity of gastric premalignant and malignant lesions in H. pylori-infected humans. A, G3BP2 expression was evaluated by immunohistochemistry in human populations at high risk for gastric cancer in Colombia and Chile. Gastric specimens from H. pylori-infected patients with nonatrophic gastritis, multifocal atrophic gastritis, intestinal metaplasia (premalignant) and gastric adenocarcinoma (malignant) were evaluated for G3BP2 immunostaining. Representative images are shown for nonatrophic gastritis, intestinal metaplasia, and gastric adenocarcinoma (200X and 400X magnification). B, A single pathologist assessed the percentage of epithelial G3BP2+ cells and the intensity of G3BP2 staining. The immunohistochemistry (IHC) score reflects the percentage of cells positive for G3BP2, multiplied by the intensity of staining, as previously described (22). Each bar indicates the average IHC score among patients with nonatrophic gastritis, multifocal atrophic gastritis or intestinal metaplasia (premalignant), or gastric adenocarcinoma (malignant) with standard error of the mean from the indicated number of patients evaluated. ANOVA tests were used to determine statistical significance among groups. ****, p < 0.0001.