Fig. 3.

Inflammatory signaling pathways were significantly altered following H. pylori infection. Ingenuity Pathway Analysis (IPA) was used to determine canonical signaling pathways that were significantly altered in H. pylori-infected animals, as compared with uninfected controls. Categorization of significantly altered pathways into biologically relevant subgroups revealed 83 inflammatory signaling pathways, the majority of which are involved in proinflammatory immune responses and immune regulation. Canonical pathways are derived from the IPA nomenclature. Statistical significance is shown in the x-axis, and each canonical pathway is listed on the y-axis.