Fig. 4.

Proliferation, differentiation, apoptosis, and cell cycle pathways were significantly altered following H. pylori infection. Ingenuity Pathway Analysis (IPA) was used to determine canonical signaling pathways that were significantly altered in H. pylori-infected animals, as compared with uninfected controls. A, There were 22 pathways significantly altered with H. pylori infection that were related to proliferation, differentiation, and apoptosis. B, There were 12 pathways significantly altered with H. pylori infection that were related to cell cycle regulation. Canonical pathways are derived from the IPA nomenclature. Statistical significance is shown in the x-axis, and each canonical pathway is listed on the y-axis.