Fig. 6.

Network analysis identified RABEP2 as an important protein in inflammatory and signaling pathways implication in the development of inflammation and cancer. Ingenuity Pathway Analysis (IPA) was used to determine significant networks that were significantly altered in H. pylori-infected animals, as compared with uninfected controls. RAPEP2 was significantly up-regulated by iTRAQ and mapped to disease pathways and networks directly involved in inflammation, cancer, and gastrointestinal disease. Green designates proteins that were significantly downregulated, whereas red indicates proteins that were significantly up-regulated. Shapes indicate different functional categories of proteins, as defined in the inset. Lines indicate interactions among proteins within the network, as defined in the inset. Arrowheads indicate stimulatory interactions, whereas endcaps indicate inhibitory interactions. Solid lines indicate direct interactions, whereas dashed lines indicate indirect interactions.