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. 2018 Nov 19;18(2):352–371. doi: 10.1074/mcp.RA118.001181

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© 2019 Noto et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 8. — H. pylori up-regulates RABEP2 in vivo in gerbil gastric epithelium in a cag-dependent manner. A, RABEP2 protein expression was evaluated by immunohistochemistry in gerbil gastric tissue sections from uninfected gerbils, and gerbils infected with wild-type cag+ H. pylori strain 7.13 or its cagE-isogenic mutant. A single pathologist assessed the percentage of epithelial RABEP2+ cells and the intensity of RABEP2 staining, as previously described (22). The immunohistochemistry (IHC) score reflects the percentage of cells positive for RABEP2, multiplied by the intensity of staining. Each bar indicates the average epithelial IHC score with standard error of the mean. B, RABEP2 protein expression was evaluated in normal gerbil gastric mucosa (n = 20) or gastric mucosa with advanced lesions (n = 7, advanced), which included gastric dysplasia and adenocarcinoma. Three cases of nonatrophic gastritis were not included in these analyses. C, Representative images of RABEP2 protein expression in normal, gastritis, or dysplastic gastric tissue sections. ANOVA tests were used to determine statistical significance among groups. *, p < 0.05; **, p < 0.005.